Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has induced a sense of panic around the world as the disease is highly contagious and has been spreading in full swing. This study was aimed to investigate SARS-CoV-2 associated epidemiology and clinical outcomes in Bangladesh in order to understand the future course of COVID-19 pandemic and develop prevention approaches. A cross-sectional retrospective interview based study was conducted on RT-PCR confirmed COVID-19 patients admitted in Chattagram Maa O Shishu General Hospital Chittagong, Bangladesh and who recovered four weeks prior to the interview date. Of the total 500 patients, 7% patient are asymptomatic where as for the symptoms associated with COVID-19 fever (85%) and cough (70%) were the most prominent among cases. Our study has revealed that among the age groups, the 40-70 showed the highest infection rate (74.7%) and in terms of gender, the prevalence of Covid-19 infection in males (65%) was 2 times more than that in females (35%). Diabetes was found about (40%) and Hypertension was found (42%), so diabetic and hypertesive patient are more affected. The most used drug is Enoxaparin sodium, Methylprednisolone Na Succinate, Montelucast, fexofenadinb, Doxycyclline, Doxofylline, zinc, vitamin-C, D and about 60% patient need oxygen supply. The most complication after recovery is weak -fatigue, cough & breathing problem.

Aim: The aim of the present project work is to understand the guidelines and regulatory requirements for investigational new drug and development of new drug Objectives: The objective of the current project include 1. Need of a new drug to investigate 2. New drug development targets 3. Understanding the properties of new dug 4. Required protocols for submission of new drug to regulatory authority 5. Regulatory requirements to get approval of new drug.

Fungi are rich sources of biologically active natural compounds, which are used in the manufacturing of wide range of clinically important drugs. Alternaria is a fungal genus that belongs to family Pleosporaceae, and has been known as a promising secondary metabolites producer. However the same fungus showed harmful pathogenicity against different plants causing crops economical losses, and is a common allergen in humans, growing indoors and causing hay fever or hypersensitivity reactions. Alternaria is a multicultural fungal genus widely distributing in soil and organic matter. It includes saprophytic, endophytic and pathogenic species. This review aims to briefly summarize the structurally different metabolites produced by Alternaria fungi, as well as their occurrences, biological activities and functions.

Cunninghamella is a fungal genus that belongs to family Cunninghamellaceae and has been involved as promising tool in many important mycotechnological applications. Cunninghamella is an endophytic fungus, their secondary metabolites are of potential biological activities especially as antimicrobial agents. The aim of this review is to highlight the description, ecology, and important in medicinal and industrial applications of the genus Cunninghamella in general. Moreover, describing the importance and potentials of this fungus in order to encourage for further studies to search, isolate, and purify already known metabolites. Also, screen for, and discover novel metabolites produced by this potent fungi in order to be involved in additional applications.